“We were promised the curing of cancer and all we got are so-and-so improvements in five-year cancer survival rates” would be a fair thing to say about progress in biomedical sciences in the last few decades. And cancer is one of the disease areas where we have done pretty well, relatively speaking. If we look at Alzheimer’s, the situation is much worse: up until 2021, we had gone for 20 years with no new drugs - and even the approved ones have marginal effects1.